Clinical Trial

Comparison of Different Epidural Lidocaine-Bupivacaine Mixtures for Lower Limb Surgeries

Study acronym: LBM-LLS
Recruiting
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Summary
This randomized controlled trial will evaluate different epidural lidocaine-bupivacaine mixtures in patients undergoing lower limb surgery at a tertiary care hospital in Karachi, Pakistan. Ninety-six participants will be randomly assigned to one of three study groups receiving different combinations of lidocaine and bupivacaine for epidural anesthesia. The purpose of this study is to determine which anesthetic mixture provides the most effective anesthesia for lower limb surgery. The study will compare the speed of onset and duration of anesthesia, as well as the effects of the anesthetic mixtures on cardiovascular stability during surgery. The results of this study may help identify an epidural anesthetic regimen that provides optimal surgical conditions, effective pain control, and stable hemodynamic parameters for patients undergoing lower limb procedures.
Trial Details
NCT Number NCT07648784
Lead Sponsor Shaheed Mohtarma Benazir Bhutto Institue of Trauma
Conditions Epidural Dosage of Lidocaine Bupivacaine in Lower Limb Surgeries
Enrollment 96 participants
Start Date 2025-12-18
Primary Completion 2026-05-20 (estimated)
Study Completion 2026-06-15 (estimated)
Updated on ClinicalTrials.gov 2026-06-15