Efficacy of Lasers, Propolis-Based Agent, and Sham for Dentine Hypersensitivity

Dentine hypersensitivity is a common clinical problem. Although Nd:YAG lasers, diode lasers, and topical desensitizing agents are widely utilized, long-term comparative evidence regarding their clinical efficacy remains limited. This prospective, randomized, parallel-arm, evaluator-blind, sham-controlled clinical trial evaluated and compared the 12-month clinical performance of an Nd:YAG laser, a diode laser, a herbal propolis-based dentin barrier agent, and a sham application.

NCT Number	NCT07647861
Lead Sponsor	Ondokuz Mayıs University
Conditions	Dentine Hypersensitivity
Enrollment	140 participants
Start Date	2025-12-15
Primary Completion	2026-06-10 (estimated)
Study Completion	2026-06-10 (estimated)
Updated on ClinicalTrials.gov	2026-06-15