Intraseptal and Periodontal Ligament Anaesthesia for Tooth Extraction in Patients With Type 2 Diabetes

The goal of this clinical trial is to compare two local anesthesia techniques, intraseptal anesthesia (ISA) and periodontal ligament anesthesia (PLA), in patients with controlled type 2 diabetes mellitus undergoing tooth extraction. The main questions it aims to answer are: Which technique provides more effective local anesthesia for tooth extraction? Do ISA and PLA differ in their effects on blood pressure and heart rate during the procedure? Researchers will compare ISA and PLA to determine which method is more effective and safer in this patient population. Participants will: Receive local anesthesia (ISA or PLA) using articaine with epinephrine delivered with a computer-controlled system Undergo extraction of a maxillary lateral incisor or mandibular first premolar Have blood pressure and heart rate measured before, during, and after anesthesia and extraction

NCT Number	NCT07647406
Lead Sponsor	University of Business Academy in Novi Sad, Serbia
Conditions	Diabetes Mellitus Type 2
Enrollment	120 participants
Start Date	2026-01-11
Primary Completion	2026-04-17 (estimated)
Study Completion	2026-05-27 (estimated)
Updated on ClinicalTrials.gov	2026-06-16