Ultrasound Muscle Biomarkers as Predictors of Isometric Quadriceps Muscle Strength and Handgrip in Healthy Adults: an Observational Study

This observational study aims to determine whether ultrasound-derived muscle biomarkers can predict isometric quadriceps muscle strength and handgrip in healthy adults aged 18-89 years. The main questions it aims to answer are: * Which ultrasound muscle characteristics are associated with isometric quadriceps muscle strength and handgrip? * Can ultrasound-derived biomarkers be used to develop predictive models of muscle strength in healthy adults? Participants will undergo: * Ultrasound assessment of the quadriceps and forearm flexor muscles; * Measurement of isometric quadriceps muscle strength and handgrip using standardized dynamometry protocols; * Assessment of functional capacity, mobility and balance; * Completion of questionnaires related to health status, physical activity, nutrition, fatigue and health-related quality of life. The study will also assess the reliability of ultrasound measurements and explore the relationship between ultrasound variables, muscle strength, physical function and health-related factors.

NCT Number	NCT07647393
Lead Sponsor	University of Alcala
Conditions	Healthy Adult, Muscle Strength, Skeletal Muscle Ultrasound
Enrollment	300 participants
Start Date	2026-06
Primary Completion	2028-06 (estimated)
Study Completion	2029-06 (estimated)
Updated on ClinicalTrials.gov	2026-06-16