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TIS for Improving Cognitive Impairment in Schizophrenia

StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 3 months later Dec 1, 2026 → Mar 1, 2027
Primary endpoint reworded 1 of 1 changed
See other at-risk trials from Central South University

Record History

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  1. Primary endpoint(s) modifiedv2 Show 6 more changesShow less
    • Recruitment opened
    • Primary completion pushed from Dec 1, 2026 to Mar 1, 2027
    • Study completion pushed from Dec 30, 2026 to Mar 30, 2027
    • Start date changed from estimate of May 30, 2026 to Jun 24, 2026
    • Site details revised
    • Study description expanded, about 1 word
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study aims to evaluate the efficacy, safety, and underlying neural mechanisms of TIS targeting the hippocampus in ameliorating cognitive impairment associated with schizophrenia (CIAS). Researchers will compare active TIS to a sham control to see if TIS works to treat CIAS. Participants will receive TIS twice a day for 2 weeks. Their clinical data, including the baseline clinical symptom scale score, cognitive function, E/I imbalance index recorded by EEG, and MRI data, will be collected at baseline, at the end of the 2-week intervention, and 4 weeks after the intervention.
Trial Details
NCT Number NCT07647380
Lead Sponsor Central South University
Conditions
(from sponsor)		 Schizophrenia Disorder, Cognitive Impairments
Related terms Cognitive Dysfunction, Schizophrenia
Enrollment 50 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov