CORonary Thrombus Modification to Prevent MIcrovascular Damage in Patients With ST-segment Elevation Myocardial Infarction (The CORMI Trial)

The aim of this study is to evaluate the effects of coronary thrombus modification on preventing the microvascular damage associated with primary percutaneous coronary intervention (PCI), and to limit the associated myocardial damage assessed by myocardial salvage index after 3 months. Furthermore, the project will evaluate coronary microvascular damage assessed invasively using both continuous and bolus thermodilution before and after stent implantation. In addition, the project will evaluate the diagnostic ability and associations of pre-stenting invasive physiological measurement to cardiac magnetic resonance imaging measurements.

NCT Number	NCT07646977
Lead Sponsor	Odense University Hospital
Conditions	ST Elevation Myocardial Infarction, Coronary Microvascular Dysfunction, Percutaneous Coronary Intervention
Enrollment	100 participants
Start Date	2026-06
Primary Completion	2029-03 (estimated)
Study Completion	2034-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-24