Clinical Trial

A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke

Study acronym: MASTRE-3
Not Yet Recruiting Phase 3
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Summary
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke. The treatment uses each participant's brain imaging to identify individualized stimulation targets related to stroke symptoms. Participants will receive either active cTBS or a sham procedure in addition to standard stroke care. The study will assess whether this personalized brain stimulation approach improves functional recovery and is safe for patients after ischemic stroke.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-06-09.
Trial Details
NCT Number NCT07645586
Lead Sponsor Beijing Tiantan Hospital
Conditions Ischemic Stroke
Enrollment 584 participants
Start Date 2026-06-15
Primary Completion 2027-09-30 (estimated)
Study Completion 2027-12-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-15