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A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke

Study acronym: MASTRE-3
StatusNot Yet Recruiting
PhasePhase 3
Started2026-10-01
View on ClinicalTrials.gov ↗

Amendment history

2026-08-16
Study Status, Outcome Measures v2
Start date2026-06-15→2026-10-01
Secondary endpoints13 entries, revised
Change from baseline in National InstitutesProportion of HealthParticipants StrokeWith ScaleEarly (NIHSS)Neurological total scoreImprovement at Day 7 EuroQol 5-Dimension 35-Level Questionnaire (EQ-5D-3L5L) healthUtility utilityIndex indexScore scoreat Day 90
2026-06-12
Study Status, Sponsor/Collaborators, Outcome Measures v1
Secondary endpoints13 entries, revised
Distribution shift in modified Rankin Scale (mRS) scoresscore Change from baseline in National Institutes of Health Stroke Scale (NIHSS) total score at Day 7 Change from baseline in Fugl-Meyer Assessment (FMA)of Motor Recovery after Stroke motor score at Day 7 Barthel Index offor Activities of Daily Living score at Day 90 EuroQol 5-Dimension 3-Level Questionnaire (EQ-5D-5L3L) health utility index score
2026-06-09
Original filing
Beijing Tiantan Hospital
280 trials monitored
See 4 trials at risk
Stroke
3,268 trials monitored
See 122 trials at risk
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke. The treatment uses each participant's brain imaging to identify individualized stimulation targets related to stroke symptoms. Participants will receive either active cTBS or a sham procedure in addition to standard stroke care. The study will assess whether this personalized brain stimulation approach improves functional recovery and is safe for patients after ischemic stroke.
Trial Details
NCT Number NCT07645586
Lead Sponsor Beijing Tiantan Hospital
Conditions Ischemic Stroke
Enrollment 584 participants
Start Date 2026-10-01
Primary Completion 2027-09-30 (estimated)
Study Completion 2027-12-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-18