FEEL-GOOD: A Multicenter Trial of a Mindfulness-Based Group Therapy in Young Adults With Early Psychosis

FEEL-GOOD is a prospective multi-site single-blinded randomized controlled trial in young inpatients with acute early psychosis. Participants are randomized 1:1 to FEEL-GOOD plus treatment as usual (TAU) or TAU alone. The intervention consists of one individual preparatory session and eight modularized group sessions delivered over four weeks involving four to eight participants at each session and including practice and homework tasks. Outcomes are assessed at baseline, 4 weeks post-intervention, and 6 months follow-up, with the primary outcome being observer-rated total psychopathology as measured with the assessed by the total score of the Positive and Negative Syndrome Scale (PANSS) post-treatment (4 weeks post baseline).

NCT Number	NCT07645443
Lead Sponsor	Stephanie Mehl Collaborators: German Research Foundation, Central Institute of Mental Health, Mannheim, Ludwig-Maximilians - University of Munich, Charite University, Berlin, Germany, Vivantes Klinikum am Urban, Philipps University Marburg, University of Cologne, Universitätsklinikum Hamburg-Eppendorf, University Hospital Augsburg
Conditions	Delusional Disorder, Brief Psychotic Disorder, Schizophreniform Disorder, Schizophrenia / Schizoaffective Disorder, Other Psychotic Disorder Not Due to A Substance or Known Physiological Condition
Enrollment	252 participants
Start Date	2026-05-27
Primary Completion	2028-09-01 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-15