Clinical Trial

Posterosuperior Bundle Pacing for Prevention of Atrial Fibrillation in Patients With Sinus Node Dysfunction

Study acronym: PSB-AF
Not Yet Recruiting
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Summary
This study aims to evaluate whether posterosuperior bundle (PSB) pacing reduces the incidence of atrial fibrillation (AF) in patients with sinus node dysfunction (SND) undergoing pacemaker implantation. Approximately 300 patients will be enrolled and randomized to receive atrial pacing at either the PSB region or the right atrial appendage (RAA). The primary endpoint is the occurrence of AF episodes lasting ≥6 minutes, as detected by device or surface electrocardiogram. Patients will be followed for up to 24 months.
Trial Details
NCT Number NCT07645066
Lead Sponsor Shanghai Tong Ren Hospital
Conditions Pacing Therapy, Cardiac Pacing
Enrollment 300 participants
Start Date 2026-08-14
Primary Completion 2029-02-01 (estimated)
Study Completion 2029-02-01 (estimated)
Updated on ClinicalTrials.gov 2026-08-04