Clinical Trial

Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery

Study acronym: KYNA-3M
Completed
View on ClinicalTrials.gov →
Summary
A prospective cohort of 40 consecutive patients with bilateral impacted mandibular third molars underwent two sequential surgical extractions separated by a two-week interval. Serum kynurenic acid (KYNA) and serotonin were measured preoperatively and 24 hours after each procedure. The study examined longitudinal dynamics of kynurenine pathway biomarkers, their variation across Pederson surgical difficulty grades, and their relationship with postoperative pain and state anxiety.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-06-08.
Trial Details
NCT Number NCT07644065
Lead Sponsor Plovdiv Medical University
Collaborators: Radka Ivanova Masaldzhieva, Dept. of Health Care Management, Faculty of Public Health, MU-Plovdiv, Mariya Vlado Ivanovska, Dept. of Microbiology and Immunology, Faculty of Medicine, MU-Plovdiv, Ralitsa Dimitrova Raycheva, Dept. of Social Medicine and Public Health, Faculty of Public Health, MU-Plovdiv
Conditions Impacted Third Molar, Postoperative Pain, Neuroinflammation, Anxiety
Enrollment 40 participants
Start Date 2019-09-30
Primary Completion 2020-05-17 (estimated)
Study Completion 2020-09-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-16