Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Surgery

Patients after hip surgery often suffer from severe pain. Inadequate analgesia increases the risk of postoperative delirium, myocardial injury, and other complications. Peripheral nerve block is an important component of multimodal analgesia, but conventional local anesthetics (such as plain bupivacaine) provide only approximately 12 hours of analgesic duration, which is far from covering the most painful 72 hours after surgery. Liposomal bupivacaine has a slow-release property, prolonging the analgesic duration up to 72 hours after a single injection. However, its clinical advantages in hip fracture surgery remain controversial. The investigators suppose that, compared with plain bupivacaine alone, preoperative supra-inguinal fascia iliaca block using liposomal bupivacaine combined with plain bupivacaine can further improve analgesia, decrease opioid consumption, and improve postoperative recovery quality within 72 hours in older patients after hip fracture surgery.

NCT Number	NCT07643792
Lead Sponsor	Peking University First Hospital
Conditions	Fascia Iliaca Block, Liposomal Bupivacaine, Postoperative Pain, Hip Surgery
Enrollment	148 participants
Start Date	2026-08
Primary Completion	2028-06 (estimated)
Study Completion	2028-08 (estimated)
Updated on ClinicalTrials.gov	2026-08-11