Clinical Trial

CleaRRAflow: Isotonic Solution vs. TPA for IVH Clearance

Enrolling by Invitation Phase 4
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Summary
The study aims to investigate the effect of continuous tPA irrigation into the ventricles. Investigators believe it may be superior to the traditional every 8-hour bolus dosing and continuous isotonic solution irrigation alone. The protocol plans to analyze blood clearance and functional outcomes in the patients.
Protocol Amendment History 1 change
critical Enrolling by invitation only 2026-08-07
Trial Details
NCT Number NCT07643493
Lead Sponsor David Dornbos
Conditions Tissue Plasminogen Activator, Intraventricular Brain Hemorrhage
Enrollment 80 participants
Start Date 2026-07-31
Primary Completion 2028-05-31 (estimated)
Study Completion 2029-05-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-06