Clinical Trial

Robot-Assisted Hematoma Evacuation With Intrahematoma Tenecteplase for Post-Reperfusion PH2 Hemorrhagic Transformation

Study acronym: REPORT
Not Yet Recruiting Phase 1
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Summary
The purpose of this phase I trial is to evaluate the safety and feasibility of robot-assisted stereotactic minimally invasive hematoma aspiration, followed when eligible by intrahematoma tenecteplase administration, in patients who develop symptomatic supratentorial PH2 hemorrhagic transformation after reperfusion therapy for acute ischemic stroke. The main study questions are whether this strategy is associated with an acceptable early rebleeding risk and whether it can achieve clinically meaningful hematoma reduction with accurate catheter placement and relief of hematoma-related mass effect.
Trial Details
NCT Number NCT07641998
Lead Sponsor Beijing Tiantan Hospital
Conditions Hemorrhagic Transformation Stroke
Enrollment 20 participants
Start Date 2026-06-10
Primary Completion 2026-12-10 (estimated)
Study Completion 2026-12-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-11