Stannous Fluoride Toothpaste for Reduction and Treatment of Gingivitis

This study evaluated the efficacy of a stannous fluoride toothpaste compared to a sodium fluoride control toothpaste in reducing gingivitis, bleeding, and plaque over a 12-week period. A total of 132 subjects were randomized to one of two treatment groups and assessed at baseline and at Weeks 2, 4, 8, and 12 using standardized clinical indices, including the Modified Gingival Index (MGI), Bleeding Index (BI), and Plaque Index (PI).

NCT Number	NCT07640399
Lead Sponsor	Church & Dwight Company, Inc.
Conditions	Gingival Inflammation, Plaque, Bleeding
Enrollment	133 participants
Start Date	2025-03-17
Primary Completion	2025-06-13 (estimated)
Study Completion	2025-06-13 (estimated)
Updated on ClinicalTrials.gov	2026-06-10