Aortic Dissection Detection Risk Score With D-dimer to Rule-Out Acute Aortic Syndrome

The goal of this study is to evaluate the safety of integrating the Aortic Dissection Detection Risk Score (ADD-RS) and D-dimer testing for ruling out acute aortic syndrome (AAS) in the emergency department (ED). The main question it aims to answer: Can the combination of the ADD-RS \<2, and D dimer \<500ng/mL rule-out AAS in ED patients without CTA? The researchers will recruit patients suspected with AAS in the ED, and the patients will receive a ADD-RS score, a D-dimer testing after signing a written consent.

NCT Number	NCT07640334
Lead Sponsor	Chinese University of Hong Kong Collaborators: Prince of Wales Hospital, Shatin, Hong Kong
Conditions	Acute Aortic Syndrome
Enrollment	448 participants
Start Date	2026-07-13
Primary Completion	2028-06-30 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-10