Pilot Studies Testing the Use of Oral Amitriptyline in Reducing Localized Burn Injury-induced Microvesicle Particle Release

The purpose of this study is to determine the amount of substances contained in skin known as microvesicle particles (MVP). The hypothesis to be tested in this study is that treatment with a single dose of 75mg of amitriptyline will block the MVP released from the skin from a very small localized burn injury.

NCT Number	NCT07640061
Lead Sponsor	Wright State University
Conditions	Microvesicle Particles, Thermal Burn
Enrollment	20 participants
Start Date	2027-06
Primary Completion	2033-06 (estimated)
Study Completion	2033-06 (estimated)
Updated on ClinicalTrials.gov	2026-06-10