Clinical Trial

TR115 VS Investigator's Choice in Relapsed/Refractory Peripheral T/NK Cell Lymphoma

Not Yet Recruiting Phase 3
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Summary
This is a randomized, open-label, multicenter Phase III study evaluating the efficacy and safety of TR115, an EZH2 inhibitor, versus investigator's choice (chidamide, golidocitinib, mitoxantrone liposome, or gemcitabine) in patients with relapsed and/or refractory peripheral T/NK-cell lymphoma. Approximately 180 patients will be randomized in a 1:1 ratio. The primary endpoint is progression-free survival (PFS) assessed by an Independent Review Committee (IRC). The key secondary endpoint is overall survival (OS). The study is being conducted at approximately 40 to 60 centers across China.
Trial Details
NCT Number NCT07639879
Lead Sponsor Tarapeutics Science Inc.
Conditions PTCL, NK T-Cell Lymphoma
Enrollment 180 participants
Start Date 2026-07-30
Primary Completion 2029-07-30 (estimated)
Study Completion 2030-07-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-10