Aprepitant to Improve Same Day Discharge for TKA

The purpose of this research is to study whether adding an FDA approved medication called aprepitant (a medication given to patients like you to reduce or eliminate nausea and vomiting) to the usual treatment to prevent nausea and vomiting given to patients during knee replacement surgery helps more patients go home on the same day of surgery (before midnight) by eliminating nausea and vomiting.

NCT Number	NCT07639723
Lead Sponsor	Endeavor Health Collaborators: Heron Therapeutics, Inc. (formerly A.P. Pharma, Inc.)
Conditions	PONV
Enrollment	350 participants
Start Date	2026-07
Primary Completion	2027-07 (estimated)
Study Completion	2027-08 (estimated)
Updated on ClinicalTrials.gov	2026-06-10