Streamlined Treatment and Evidence-based Adolescent Counseling and Medication Support (STREAMS)

Combination interventions to address mental health and adherence to HIV care in low- and middle-income countries (LMICs), are crucial to achieving the UNAIDS 95-95-95 targets as one in four adolescents living with HIV (ALWHIV) experience poor mental health and this contributes to suboptimal medication adherence and lack of viral suppression. Yet few evidence-based mental health and adherence interventions have been evaluated in sub-Saharan Africa (SSA), the region where the majority of the 1.7 million ALWHIV reside. STREAMS will determine if our streamlined combination intervention approach to mental health screening, provision of evidence-based interpersonal psychotherapy groups (IPT-G), and evidence-based family strengthening, and medication counseling is feasible and efficacious for ALWHIV in Uganda.

NCT Number	NCT07637058
Lead Sponsor	City University of New York, School of Public Health Collaborators: National Institute of Mental Health (NIMH), New York University, Washington University Bursky School of Public Health
Conditions	Depression in Adolescence
Enrollment	588 participants
Start Date	2026-12
Primary Completion	2028-12 (estimated)
Study Completion	2030-08 (estimated)
Updated on ClinicalTrials.gov	2026-06-09