Multimodal Opioid-Free Anesthesia in RIRS

The goal of this clinical trial is to evaluate whether a dexmedetomidine-ketamine based opioid-free anesthesia (OFA) protocol can provide effective analgesia compared to conventional fentanyl-based anesthesia in adult patients undergoing elective retrograde intrarenal surgery (RIRS). The main questions it aims to answer are: Does opioid-free anesthesia reduce postoperative opioid consumption compared to fentanyl-based anesthesia? Does opioid-free anesthesia result in lower postoperative pain scores? Researchers will compare the dexmedetomidine-ketamine group to the fentanyl-based anesthesia group to see if opioid-free anesthesia reduces opioid requirements and improves recovery quality. Participants will receive either a dexmedetomidine-ketamine based OFA protocol or conventional fentanyl-based anesthesia during surgery and will be monitored for pain, opioid consumption, and recovery outcomes postoperatively.

NCT Number	NCT07636070
Lead Sponsor	murat sahin
Conditions	Kidney Stone, Retrograde Intrarenal Surgery (RIRS), Postoperative Pain
Enrollment	60 participants
Start Date	2026-06-01
Primary Completion	2026-08-01 (estimated)
Study Completion	2026-08-10 (estimated)
Updated on ClinicalTrials.gov	2026-06-09