Clinical Trial

New Triple Combination Therapy in Newly Diagnosed Type 2 Diabetes

Not Yet Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
The goal of this clinical trial is to learn the efficacy of combination therapy with tirzepatide, empagliflozin and pioglitazone versus standard therapy in newly diagnosed type 2 diabetes. The main objectives to achieve are: 1. To compare efficacy of the triple combination therapy against standard therapy in achieving type 2 diabetes remission in patients newly diagnosed with T2DM. 2. To compare the effects on β-cell function and glycemic control of the triple combination therapy against standard therapy in patients newly diagnosed with T2DM Researchers will compare drug new triple combination therapy with tirzepatide, empagliflozin, and pioglitazone to standard therapy (metformin based treatment) to see if new triple combination therapy works better in achieving type 2 diabetes remission. Participants will: 1. Take new triple combination therapy or a standard therapy every day for 6 months 2. Visit the clinic once every 0.5-1 month for checkups and tests 3. Keep a diary of their fingertip blood glucose and adverse events
Trial Details
NCT Number NCT07635953
Lead Sponsor Sun Yat-sen University
Conditions Diabetes Mellitus
Enrollment 296 participants
Start Date 2026-07-01
Primary Completion 2029-07-01 (estimated)
Study Completion 2031-07-01 (estimated)
Updated on ClinicalTrials.gov 2026-06-09