The goal of this observational study is to find clinical, demographic, and protein biomarkers that scoliosis progression (scoliosis curve increases) and/or differ between participants with scoliosis versus those without scoliosis. The investigators aim to answer the following questions:
1. Are age, sex, skeletal maturity, and family history associated with scoliosis curve progression?
2. Do protein levels differ between progressive and non-progressive cases?
3. Do protein levels change between baseline and follow-up visits in progressive and non-progressive scoliosis cases?
4. Do proteins differ between participants with AIS vs those without AIS?
5. Do proteins or change in proteins differ between participants with AIS vs those with scoliosis secondary to neuromuscular conditions.
Participants will:
* Participate in two research visits 6-12 months apart at a Children's Hospital Colorado location.
* Participate in a blood draw at each study visit to collect about 3 tablespoons of blood.
* Fill out surveys yearly regarding new medical visits, pain, physical function, anxiety and depression, medical and family history, and current medications.