Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment

The IMPACT study is a randomized, double-blind clinical trial evaluating two commonly used intravenous medications - metoclopramide and acetaminophen - for treating acute post-concussion symptoms in emergency department patients after mild head injury. The study aims to determine which treatment more effectively improves symptoms such as headache, dizziness, nausea, concentration difficulties, and emotional changes within the first week after injury. Participants will be enrolled across two Montefiore emergency departments and followed using a validated post-concussion symptom questionnaire. Findings from this study may help improve evidence-based treatment strategies for patients experiencing concussion-related symptoms after head trauma.

NCT Number	NCT07634393
Lead Sponsor	Montefiore Medical Center
Conditions	Concussion Post Syndrome, Head Trauma Injury
Enrollment	200 participants
Start Date	2026-08-01
Primary Completion	2028-06-30 (estimated)
Study Completion	2028-08-04 (estimated)
Updated on ClinicalTrials.gov	2026-06-10