Health Effects of Ultra-processed Food Intake

Study acronym: UPFront

StatusRecruiting

PhaseNot applicable

SponsorGöteborg University

Started2026-06-25

View on ClinicalTrials.gov ↗

Amendment history

2026-08-21

Study Status, Study Description, Outcome Measures, Eligibility, Contacts/Locations v1

Recruitment opened

Start dateestimated 2026-08→confirmed 2026-06-25

Eligibility criteria+119 characters

[...] hange weight Willing to eat the study diet and a mixed diet Habitually eats breakfast, lunch and dinner Has provided informed consent to participate in the study Ex [...] ay participate if they take enzymes. BMI <18.5 or >35 kg/m² >8h/week of intense physical activity Use of medications known to significantly affect appetite (e [...] , or plans to become pregnant or breastfeed during the study Deemed likely to have poor adherence

Secondary endpointsdetails revised at 1 of 13 entries

Study sitesdetails revised at 1 of 1 site

2026-06-03

Original filing

Göteborg University

73 trials monitored

See 6 trials at risk

Ultra-processed food (UPF) intake has been related to negative health effects and increased energy intake in previous intervention studies. Thus, previous studies have seen weight gain from higher UPF intake which obscures the potential to see effects on cardiometabolic biomarkers, independent of weight changes. The overall aim of this project is to study the causal effects of a high UPF diet, compared to a nutrient-matched low UPF diet, on appetite and cardiometabolic health in a weight-stable context.

Trial Details

NCT Number	NCT07634159
Lead Sponsor	Göteborg University Collaborators: Chalmers University of Technology, Karolinska Institutet
Conditions	Cardiometabolic Risk Factors, Microbiota, Diet Interventions
Enrollment	40 participants
Start Date	2026-06-25
Primary Completion	2027-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-08-24