End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest

The investigators aim to assess the relationship between patient characteristics, prehospital treatments, and vital signs to determine if a threshold EtCO2 value, a change in EtCO2 value (final - initial), or a trend in EtCO2 (positive/negative) is a better predictor of patient survival to discharge. The secondary aim of this project is to identify significant predictors of neurologically intact patient survival as indicated by a cerebral performance category (CPC) score of 1-2.

NCT Number	NCT07632430
Lead Sponsor	Office of the Medical Director for EMS in Oklahoma City and Tulsa Collaborators: Medtronic
Conditions	Prehospital Resuscitation, End-Tidal Carbon Dioxide, Cardiac Arrest, Out-Of-Hospital, Prehospital Emergency Medical Services
Enrollment	3,500 participants
Start Date	2024-01-01
Primary Completion	2025-07-01 (estimated)
Study Completion	2026-09-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-09