Clinical Trial

Effects of Standard and Modified Z-Trendelenburg Positions on Cerebral Oxygenation and Optic Nerve Sheath Diameter

Study acronym: MOD-TREND
Completed
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Summary
The purpose of this study is to compare the effects of the standard Trendelenburg position and the modified Z-Trendelenburg position on cerebral oxygenation and optic nerve sheath diameter (ONSD) in patients undergoing laparoscopic surgery. The prolonged use of the standard Trendelenburg position combined with pneumoperitoneum can increase intracranial pressure and affect cerebral blood flow. In this study, researchers will use non-invasive methods, including Near-Infrared Spectroscopy (NIRS) to monitor regional cerebral oxygenation, and ocular ultrasonography to measure ONSD as an indicator of intracranial pressure changes. The main goal is to determine whether the modified Z-Trendelenburg position serves as a safer physiological alternative by reducing these potential adverse effects compared to the standard position.
Trial Details
NCT Number NCT07632287
Lead Sponsor Ankara Etlik City Hospital
Conditions Laparoscopic Gynecological Surgery
Enrollment 70 participants
Start Date 2026-03-06
Primary Completion 2026-05-18 (estimated)
Study Completion 2026-05-18 (estimated)
Updated on ClinicalTrials.gov 2026-06-08