Ondansetron Versus Lidocaine for Preventing Pain on Propofol Injection.

This is a prospective, single-center, randomized, double-blind controlled trial involving patients scheduled for elective surgery requiring general anesthesia with propofol induction. Participants are randomly assigned to one of three groups: the ondansetron group (8 mg IV), the lidocaine group (40 mg IV), or the control group (0.9% normal saline placebo). Study medications are administered intravenously over 5 minutes, ending 1 minute before anesthetic induction. the goal: To assess the efficacy of intravenous ondansetron versus lidocaine and placebo in reducing the incidence and intensity of pain associated with propofol injection in patients undergoing general anesthesia.

NCT Number	NCT07632144
Lead Sponsor	Mongi Slim Hospital
Conditions	Anesthesia Induction, Propofol Pain Injection
Enrollment	156 participants
Start Date	2026-06-08
Primary Completion	2026-07-30 (estimated)
Study Completion	2026-08-15 (estimated)
Updated on ClinicalTrials.gov	2026-06-08