Clinical Trial

Pseudoallergen-Free and Low-Histamine Diet in Adolescents With Chronic Spontaneous Urticaria

Study acronym: PAF-LH-CSU
Enrolling by Invitation
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Summary
The goal of this clinical trial is to learn whether a histamine- and pseudoallergen-restricted diet can help reduce symptoms in people with chronic urticaria. It will also learn whether this diet changes the need for urticaria medication. The main questions it aims to answer are: Does the diet lower urticaria activity, including hives and itching? Does the diet improve disease control and quality of life? Does the diet change the need for urticaria medication? Which clinical or laboratory factors may affect response to the diet? There is no comparison group. Researchers will compare participants' symptoms before and after the diet. Participants will: Follow a structured histamine- and pseudoallergen-restricted diet Continue their usual urticaria treatment as recommended by their doctor Record or report their urticaria symptoms during follow-up Visit the clinic for assessment of symptoms, disease control, quality of life, medication use, and laboratory findings.
Trial Details
NCT Number NCT07632040
Lead Sponsor Istanbul University
Conditions Pediatric Chronic Spontaneous Urticaria
Enrollment 120 participants
Start Date 2025-11-24
Primary Completion 2026-11-24 (estimated)
Study Completion 2027-01 (estimated)
Updated on ClinicalTrials.gov 2026-06-08