Clinical Trial

Acute Intermittent Hypoxia Combined With Gait Training in Multiple Sclerosis

Study acronym: MINT
Not Yet Recruiting
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Summary
This interventional, randomized, sham-controlled study will examine whether Acute Intermittent Hypoxia (AIH) delivered immediately before Myoelectric Interface Neurorehabilitation Training (MINT)-based locomotor training improves gait in people with Multiple Sclerosis. The primary objectives are to evaluate changes in gait speed and endurance, with secondary objectives assessing spatiotemporal gait parameters, fatigue, and safety. Participants will receive AIH or sham priming followed by standardized treadmill and/or overground gait training, with outcome measures collected before and after the intervention across multiple sessions.
Trial Details
NCT Number NCT07631923
Lead Sponsor Shirley Ryan AbilityLab
Conditions Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis (MS) Primary Progressive, Multiple Sclerosis (MS) Secondary Progressive
Enrollment 35 participants
Start Date 2026-06-15
Primary Completion 2028-01-01 (estimated)
Study Completion 2028-06-01 (estimated)
Updated on ClinicalTrials.gov 2026-06-08