Change in Platelet Lipid Metabolism and Procoagulant Phenotype Induced by Cardiopulmonary Bypass. Impact on Postoperative Inflammatory Response and Bleeding Complications During Cardiac Surgery.

The PLACARD research project aims to investigate the impact of CPB-induced platelet modifications during cardiac surgery on the post-operative inflammatory response and bleeding complications. Our objectives are to study the impact of CPB on the formation of procoagulant platelets, to assess changes in platelet lipid profile and bioenergetics before, during and after cardiac surgery, and to connect the ex-vivo observations to post-operative clinical and biological parameters of these patients during their stay in cardiovascular intensive care unit.

NCT Number	NCT07630987
Lead Sponsor	Université Catholique de Louvain Collaborators: Fonds National de la Recherche Scientifique, Fondation Mont-Godinne
Conditions	Cardiac Surgery, Cardiopulmonary Bypass, Platelet Activation
Enrollment	100 participants
Start Date	2026-05-15
Primary Completion	2029-01 (estimated)
Study Completion	2030-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-05