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Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement

Study acronym: FEM-COMB
StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. Notable Recruitment opened Show 6 more changesShow less
    • Lead sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche to GCS Ramsay Santé pour l'Enseignement et la Recherche
    • Start date changed from estimate of May 25, 2026 to May 26, 2026
    • Eligibility criteria expanded, about 15 words
    • Secondary endpoints: details revised at 3 of 10 entries
    • Site details revised
    • Publications: details revised at 13 of 15 entries
  2. Notable Changed Sponsor changed: Ramsay Générale de Santé to GCS Ramsay Santé pour l'Enseignement et la Recherche
  3. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery. The main questions it aims to answer are: * Does the combined distal femoral nerve block reduce the amount of opioid needed in the post-anesthesia recovery room? * Does it preserve quadriceps muscle strength while improving postoperative pain control? Researchers will compare the combined distal femoral nerve block to a saphenous nerve block alone to see if the combined block provides better analgesia without reducing leg strength. Participants will: * Receive either the combined distal femoral nerve block or the saphenous nerve block alone before surgery. * Also receive standard multimodal pain management, including anesthesia, surgical site infiltration, and postoperative pain medications. * Be assessed for pain, opioid use, nausea and vomiting, quadriceps strength, time to first standing, hospital stay length, and patient satisfaction from surgery until discharge.
Trial Details
NCT Number NCT07629388
Lead Sponsor GCS Ramsay Santé pour l'Enseignement et la Recherche
Conditions
(from sponsor)
Pain After Total Knee Arthroplasty, Pain Management
Related terms Agnosia, Postoperative Pain
Enrollment 240 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov