Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement

The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery. The main questions it aims to answer are: * Does the combined distal femoral nerve block reduce the amount of opioid needed in the post-anesthesia recovery room? * Does it preserve quadriceps muscle strength while improving postoperative pain control? Researchers will compare the combined distal femoral nerve block to a saphenous nerve block alone to see if the combined block provides better analgesia without reducing leg strength. Participants will: * Receive either the combined distal femoral nerve block or the saphenous nerve block alone before surgery. * Also receive standard multimodal pain management, including anesthesia, surgical site infiltration, and postoperative pain medications. * Be assessed for pain, opioid use, nausea and vomiting, quadriceps strength, time to first standing, hospital stay length, and patient satisfaction from surgery until discharge.

NCT Number	NCT07629388
Lead Sponsor	Ramsay Générale de Santé
Conditions	Pain After Total Knee Arthroplasty, Pain Management
Enrollment	240 participants
Start Date	2026-05-25
Primary Completion	2027-05-25 (estimated)
Study Completion	2027-05-25 (estimated)
Updated on ClinicalTrials.gov	2026-06-05