Clinical Trial

Complementary Herbal Approach to Rheumatoid Management Study (CHARMS)

Study acronym: CHARMS
Not Yet Recruiting Phase 2/3
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Summary
Rheumatoid Arthritis (RA) is a chronic disease characterised by symmetric, polyarticular pain and swelling, involving small joints of the hands and feet. RA can lead to irreversible joint damage without treatment, causing disability and impacting daily activities and work productivity. Some patients turn to Chinese Herbal Medication (CHM) for treatment. Since there is currently no well designed randomised controlled trial to support the 'real-world' use of Si Miao Xiao Bi Tang with anti-rheumatic drugs, such as methotrexate, the investigators are conducting a 12-week, randomised double-blinded placebo-controlled trial to determine the efficacy, safety and cost effectiveness of a modified Si Miao Xiao Bi Tang, a type of CHM, in the treatment of patients with active RA.
Trial Details
NCT Number NCT07627893
Lead Sponsor Singapore General Hospital
Collaborators: Thong Chai Institute of Medical Research
Conditions Rheumatoid Arthritis (RA)
Enrollment 132 participants
Start Date 2026-06-01
Primary Completion 2029-05-31 (estimated)
Study Completion 2030-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-04