Clinical Trial

WMT for Recurrent Urinary Tract Infections

Study acronym: WMT-rUTI
Completed Phase 1/2
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Summary
his is a single-center, prospective, single-arm, interventional clinical study to evaluate the clinical efficacy, safety, and potential mechanisms of washed microbiota transplantation (WMT) in patients with recurrent urinary tract infections (rUTI). Recurrent UTI is defined as ≥2 episodes within 6 months or ≥3 episodes within 1 year. Traditional management relies heavily on antibiotics, which often lead to gut dysbiosis and increased infection risk. WMT may reconstruct intestinal microbiota, restore colonization resistance, and modulate immunity through the gut-bladder axis. Approximately 30 eligible patients will receive WMT via mid-gut or colonic transendoscopic enteral tubing (TET) for 2-3 times according to the Nanjing Consensus on Washed Microbiota Transplantation. Participants will be followed for 12 months.
Trial Details
NCT Number NCT07627412
Lead Sponsor The Second Hospital of Nanjing Medical University
Conditions Recurrent Urinary Tract Infections, Urinary Tract Infections
Enrollment 30 participants
Start Date 2022-08-01
Primary Completion 2024-08-30 (estimated)
Study Completion 2024-08-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-04