Clinical Trial

Increasing Uptake of Cascade Testing in Families With Familial Cancer Syndromes: A Randomized Controlled Trial of a Registry-aided Model.

Completed
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Summary
The purpose of this study is to compare the uptake rates of a patient-initiated model of cascade testing with a registry-aided model amongst relatives of patients identified to have a particular cancer predisposition gene. Cascade testing allows the benefits of genetic testing to spread beyond the patient and enables other family members to make an informed choice on genetic testing. The researcher team hopes to study the rates of cascade testing using the two models, while concurrently comparing the adherence of identified carriers to risk management recommendations, including surveillance imaging and/or prophylactic surgeries. The team also aims to understand the willingness, acceptability and barriers of a registry-aided model.
Trial Details
NCT Number NCT07626814
Lead Sponsor National Cancer Centre, Singapore
Conditions Hereditary Cancer Syndromes
Enrollment 545 participants
Start Date 2021-12-10
Primary Completion 2026-02-06 (estimated)
Study Completion 2026-02-06 (estimated)
Updated on ClinicalTrials.gov 2026-06-04