Early Lumbar Drainage for Intraventricular Hemorrhage

This is a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial comparing the addition of early lumbar drainage to standard care in patients with intraventricular hemorrhage (IVH) in China. The primary objective is to evaluate whether early lumbar drainage improves long-term functional outcomes at 180 days, as measured by the modified Rankin Scale (mRS), and reduces complications in patients treated with external ventricular drainage (EVD) and intrathecal urokinase.

NCT Number	NCT07625449
Lead Sponsor	Second Affiliated Hospital of Nanchang University Collaborators: Shanghai Jiao Tong University School of Medicine
Conditions	Intraventricular Hemorrhage, Cerebral Hemorrhage
Enrollment	392 participants
Start Date	2026-06
Primary Completion	2029-10 (estimated)
Study Completion	2029-10 (estimated)
Updated on ClinicalTrials.gov	2026-06-04