Impact of Atrioventricular Delay Optimization on Ventricular Function in Conduction System Pacing

Conduction system pacing has emerged as a physiological pacing strategy that preserves ventricular electrical activation and minimizes pacing-induced dyssynchrony. However, the optimal atrioventricular delay setting in patients undergoing conduction system pacing remains uncertain. This study aims to evaluate the effects of individualized echocardiography-guided atrioventricular delay optimization on ventricular function and hemodynamic performance in patients with conduction system pacing. Echocardiographic parameters including global longitudinal strain, left ventricular ejection fraction, left ventricular outflow tract velocity-time integral, cardiac output, and diastolic function indices will be assessed before and after atrioventricular delay optimization. The study will investigate whether optimization of atrioventricular timing provides additional mechanical and hemodynamic benefits beyond physiological ventricular activation achieved by conduction system pacing alone.

NCT Number	NCT07624552
Lead Sponsor	Bursa Yuksek Ihtisas Training and Research Hospital
Conditions	Atrioventricular Block, Conduction System Pacing
Enrollment	39 participants
Start Date	2025-10-06
Primary Completion	2026-02-17 (estimated)
Study Completion	2026-02-17 (estimated)
Updated on ClinicalTrials.gov	2026-06-08