Vonoprazan High-Dose Dual VS Levofloxacin Concomitant

This is a randomized controlled trial comparing the efficacy and safety of two vonoprazan-based regimens: high-dose dual therapy (vonoprazan plus a single antibiotic) versus triple therapy (vonoprazan plus two antibiotics) for the treatment of H. pylori infection). Participants will be randomly assigned to receive either regimen for 14 days. The primary outcome is eradication rate , and secondary outcomes include adverse events and treatment adherence.

NCT Number	NCT07624422
Lead Sponsor	Damascus Hospital
Conditions	Helicobacter Pylori Infection, Peptic Ulcer Disease, Gastritis
Enrollment	150 participants
Start Date	2026-11-01
Primary Completion	2027-12-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-03