PNF Versus Cryotherapy in Delayed Onset Muscle Soreness

This randomized, double-blind, single-center pilot clinical trial evaluated three interventions for delayed onset muscle soreness in the hamstring muscles. Twenty-nine untrained adults were included. Delayed onset muscle soreness was induced using two eccentric hamstring exercises. Participants were then assigned to one of three groups: proprioceptive neuromuscular facilitation, local cryotherapy, or placebo consisting of water with sugar. The main outcome was pressure pain threshold in the hamstring muscles. Other outcomes included knee range of motion, hamstring strength, pain intensity, perceived exertion, and blood lactate levels. Measurements were taken before the eccentric exercise, 24 hours after exercise before treatment, immediately after treatment, and 48 hours after exercise.

NCT Number	NCT07624032
Lead Sponsor	Universidad Pontificia de Salamanca
Conditions	Delayed Onset Muscle Soreness (DOMS)
Enrollment	29 participants
Start Date	2025-01-01
Primary Completion	2025-04-26 (estimated)
Study Completion	2025-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-16