Characterisation of Functional and Cognitive Responses Following Olfactory Stimulation and/or Functional Training in Older Adults.

This randomized controlled trial will evaluate the effects of olfactory stimulation and/or multicomponent physical training in adults aged 60 years and older. Eligible participants will be cognitively normal, community-dwelling outpatients recruited from Primary Care and Geriatrics services. After baseline assessment, participants will be randomized to one of four groups: usual care, olfactory training/stimulation, multicomponent physical exercise, or combined olfactory and exercise intervention. Primary and secondary assessments will include olfactory function, cognition, physical function, quality of life, nutritional status, mood, frailty, multimorbidity, polypharmacy, blood-based molecular biomarkers, and exhaled-air biomarkers.

NCT Number	NCT07623122
Lead Sponsor	Fundacion Miguel Servet Collaborators: Hospital of Navarra
Conditions	Healthy Aging, Frailty, Cognitive Decline, Olfactory Dysfunction, Physical Performance Decline in Older Adults
Enrollment	120 participants
Start Date	2024-06-06
Primary Completion	2025-12-04 (estimated)
Study Completion	2025-12-04 (estimated)
Updated on ClinicalTrials.gov	2026-06-03