The Implementation of Genetic Risk for Colorectal Cancer Screening

The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1. How does knowledge of a patient's genetic risk for colorectal cancer affect the uptake of initial screening colonoscopies? 2. How do colonoscopy outcomes compare between genetic risk groups?

NCT Number	NCT07621757
Lead Sponsor	Endeavor Health
Conditions	Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp
Enrollment	100 participants
Start Date	2026-06-01
Primary Completion	2027-01-31 (estimated)
Study Completion	2027-05-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-02