Opiranserin for Minimally Invasive Cholecystectomy

The purpose of this study is to evaluate whether the combination therapy of opiranserin and acetaminophen is non-inferior to the combination of non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen for postoperative pain management after minimally invasive cholecystectomy. This is a single-center, randomized, controlled, non-inferiority clinical trial in adult patients undergoing minimally invasive cholecystectomy. Participants will be randomly assigned to either the Treatement group (opiranserin + acetaminophen) or the control group (NSAIDs + acetaminophen) in a 1:1 ratio to compare the analgesic efficacy and safety between the two analgesic regimens.

NCT Number	NCT07620665
Lead Sponsor	Gangnam Severance Hospital
Conditions	Cholecystectomy, Laparoscopic, Cholecystectomy, Robotic
Enrollment	88 participants
Start Date	2026-06-10
Primary Completion	2028-05-25 (estimated)
Study Completion	2028-05-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-18