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Topical Insulin for Glaucoma (TING2)

StatusEnrolling by Invitation
PhasePhase 1/2
Started
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Record History

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  1. Enrolling by invitation only Show 5 more changesShow less
    • Start date changed from estimate of Jun 2026 to Sep 10, 2026
    • Interventions: EYED-002 (highest tolerated dose, 12-month) (Drug), EYED-002 High Dose (1442 U/mL topical insulin) (Drug), EYED-002 Low Dose (721 U/mL… to EYED-002 (highest tolerated dose, 12-month) (Drug), EYED-002 High Dose (1442 U/mL topical insulin) (Drug), EYED-002 Low Dose (721 U/mL…
    • Eligibility criteria expanded, about 12 words
    • Site contact updated
    • Publications: details revised at 2 of 2 entries
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study evaluates the safety and preliminary efficacy of topical sterile human insulin eye drops (EYED-002) in patients with open-angle glaucoma. The study uses a phase 1/2 dose-escalation design followed by a masked, randomized, placebo-controlled phase. Insulin is formulated as preservative-free eye drops and delivered once daily. The primary objective is to determine the safety profile of topical insulin; secondary objectives assess effects on retinal structure, visual field, visual acuity, contrast sensitivity, and quality of life.
Trial Details
NCT Number NCT07619482
Lead Sponsor Stanford University
Conditions
(from sponsor)		 Open Angle Glaucoma, Primary Open Angle Glaucoma, Low Tension Glaucoma, Pigmentary Glaucoma, Pseudoexfoliation Glaucoma
Related terms Exfoliation Syndrome, Glaucoma, Glaucoma, Open-Angle, Low Tension Glaucoma
Enrollment 90 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov