Effect of Bioactive Restorative Materials on Secondary Caries Prevention

This manuscript presents a 24-month randomised clinical trial evaluating the effectiveness of bioactive restorative materials in preventing secondary caries compared with conventional composite restorations. Four restorative materials were tested in 120 class I and II cavities among high-caries-risk adults: conventional composite (Filtek Z350 XT), glass ionomer cement (Fuji IX GP), giomer (Beautifil II), and Cention N.

NCT Number	NCT07619378
Lead Sponsor	Jouf University
Conditions	Secondary Caries
Enrollment	120 participants
Start Date	2023-05-01
Primary Completion	2025-05-01 (estimated)
Study Completion	2025-05-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-02