Clinical Trial

A Clinical Study Comparing Ankle Swelling Caused by Two Different Blood Pressure Medications, Levamlodipine and Amlodipine, in Post-menopausal Women With Mild High Blood Pressure.

Study acronym: TERESA
Not Yet Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
High blood pressure is often treated with a medication called Amlodipine, but it can cause uncomfortable ankle swelling, especially in women. This 18-week study compares standard Amlodipine with a more purified version called Levamlodipine to see if it causes less ankle swelling while still effectively lowering blood pressure. The study is designed for post-menopausal women aged 50 to 79 with mild to moderate high blood pressure. Participants will take a daily pill and attend four clinic visits. During these visits, doctors will monitor blood pressure and carefully measure ankle volume using a simple, painless water bath method.
Trial Details
NCT Number NCT07618806
Lead Sponsor Zentiva, k.s.
Conditions Hypertension, Oedema
Enrollment 344 participants
Start Date 2026-11-30
Primary Completion 2027-12-31 (estimated)
Study Completion 2028-05-31 (estimated)
Updated on ClinicalTrials.gov 2026-06-01