A Computational Neuroscience Perspective on the Shared Social Cognitive Deficits of Autism and Schizophrenia

This retrospective cohort study will examine shared neural mechanisms of social cognitive deficits in adults with autism spectrum disorder and adults with schizophrenia using existing clinical, behavioral, and neuroimaging data from National Taiwan University Hospital cohort studies. The study will include adults with autism spectrum disorder, adults with schizophrenia, and healthy control participants. Resting-state functional magnetic resonance imaging (MRI) and structural MRI data will be analyzed to estimate default mode network functional transition indices. These indices will be compared between diagnostic groups and examined in association with social cognitive and psychiatric symptom measures, including the Social Responsiveness Scale (SRS) and the Positive and Negative Syndrome Scale (PANSS) when applicable. No new participants will be recruited, and no intervention will be administered. The study will use previously collected data from 80 adults with autism spectrum disorder, 79 adults with schizophrenia, and 108 healthy controls.

NCT Number	NCT07618767
Lead Sponsor	National Taiwan University Hospital
Conditions	Schizophrenia, Autism Spectrum Disorder
Enrollment	267 participants
Start Date	2025-09-30
Primary Completion	2026-07-23 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-08