Pro-urokinase for Extended-Window Posterior Circulation Stroke

This study aims to evaluate whether, in patients with imaging-confirmed acute ischemic stroke of the posterior circulation presenting within 4.5-24 hours after symptom onset and not scheduled for endovascular thrombectomy, intravenous thrombolysis with recombinant human prourokinase (rhPro-UK), compared with standard medical treatment, can achieve superior 90-day functional outcomes with a higher level of safety.

NCT Number	NCT07617870
Lead Sponsor	The First Affiliated Hospital of Zhengzhou University
Conditions	Acute Ischemic Stroke
Enrollment	586 participants
Start Date	2026-06-01
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-01