Selective Mediastinal Lymph Node Sampling Versus Systematic medIastinal Lymph Node Dissection After Neoadjuvant Chemoimmunotherapy for Non-small Cell Lung Cancer (SCIENCE Study)

The SCIENCE trial is a multicenter, open-label, randomized, parallel, noninferiority investigator-initiated trial (IIT). This study aims to evaluate the prognostic differences between selective mediastinal lymph node sampling and systematic mediastinal lymph node dissection in patients with node-negative stage IIA to IIIB (N2) non-small-cell lung cancer (NSCLC) undergoing anatomical lobectomy following neoadjuvant chemoimmunotherapy.

NCT Number	NCT07617389
Lead Sponsor	Wen-zhao ZHONG Collaborators: Shanghai Junshi Bioscience Co., Ltd.
Conditions	Stage IIA-IIIB NSCLC, Selective Mediastinal Lymph Node Sampling, Systematic medIastinal Lymph Node Dissection
Enrollment	358 participants
Start Date	2026-05-20
Primary Completion	2030-05-15 (estimated)
Study Completion	2030-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-01