Dynamic Trajectories of Pupillary Light Reflex Parameters and Prognosis in Critically Ill Patients: A Multicenter Prospective Cohort Study

This multicenter prospective observational cohort study aims to investigate the association between early dynamic trajectories of pupillary light reflex parameters and clinical outcomes in critically ill patients admitted to emergency intensive care units. Quantitative pupillometry will be performed during the first 7 days after EICU admission. Constriction velocity will be the primary parameter for trajectory analysis, while dilation velocity, pupil diameter, constriction percentage, maximum constriction velocity, and latency will be analyzed as supplementary parameters. The study will evaluate whether these dynamic pupillary trajectories are associated with discharge outcome and 90-day functional outcome assessed by the Glasgow Outcome Scale-Extended.

NCT Number	NCT07616518
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University Collaborators: Zhejiang Provincial People's Hospital, Zhejiang Provincial Tongde Hospital, Jinhua Municipal Central Hospital, Huzhou Central Hospital, Lishui Country People's Hospital, Lishui Municipal Central Hospital, Ningbo Medical Center Lihuili Hospital, The Second Affiliated Hospital of Jiaxing University, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, People's Hospital of Quzhou, First People's Hospital of Hangzhou
Conditions	Critical Illness, Pupillometry, Prognosis
Enrollment	700 participants
Start Date	2026-06-06
Primary Completion	2026-10-13 (estimated)
Study Completion	2026-10-13 (estimated)
Updated on ClinicalTrials.gov	2026-06-01