AGEWISE: Unravelling the Gut-Hormone Axis in Women's Ageing

AGEWISE is an observational study that aims to understand how changes in gut microbiome are related to hormonal changes during women's ageing, particularly across the different stages of menopause. The study will include healthy women aged 40 to 64 years living in Portugal, who will provide stool and blood samples and complete questionnaires about their health, lifestyle, diet, and menopausal symptoms. Researchers will study the gut microbiome together with hormone levels and markers of inflammation to better understand how menopause affects long-term health and to support the development of improved prevention strategies for women.

NCT Number	NCT07614542
Lead Sponsor	Gulbenkian Institute for Molecular Medicine Collaborators: Biocodex Microbiota Foundation
Conditions	Menopause, Gut Microbiome, Hormonal Changes, Chronic Low-Grade Inflammation, Inflammaging
Enrollment	300 participants
Start Date	2025-06-02
Primary Completion	2026-12 (estimated)
Study Completion	2036-12 (estimated)
Updated on ClinicalTrials.gov	2026-05-29