Clinical Trial

Prediction of Local Anaesthetic Dosing During Labour Epidural Analgesia

Study acronym: DIANA
Not Yet Recruiting
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Summary
Epidural analgesia is the gold standard for controlling labour pain. However, labour pain happens during neuraxial analgesia, due to anaesthetic, obstetric, maternal factors. The investigators hypothesized that relevant variables, able to predict the local anaesthetic (LA) requirement during labour, can be identified at admission and each parturient may therefore be accordingly classified in "low-requirement" and "high-requirement". In this way, a predictive score may be developed, and the analgesic regimen may be matched to the individual patient, thus ensuring a timely and appropriate treatment of patients likely to require higher doses of LA, while minimizing potentially side effects of excessive treatment in the low-dose group.
Trial Details
NCT Number NCT07614516
Lead Sponsor Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions Labour Analgesia
Enrollment 12,500 participants
Start Date 2026-06-13
Primary Completion 2026-09-30 (estimated)
Study Completion 2026-10-31 (estimated)
Updated on ClinicalTrials.gov 2026-05-29